India on Monday defeated Windies by 224 runs to claim their 4th biggest victory in ODIs.
Windies were bowled out for 154 runs while chasing a target of 378 at Brabourne Stadium, Mumbai.
Khaleel Ahmed and Kuldeep Yadav claimed 3 wickets each.
Skipper, Jason Holder top scored with an unbeaten 54 runs.
Earlier, India posted 377/5 that included centuries by Rohit Sharma (162) and Ambati Rayudu (100).
The fifth and last ODI match will be played at Thiruvananthpuram on Nov 1.
India leads the series 2-1.